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These bioactive molecules often act on numerous molecular pathways simultaneously, conferring broad therapeutic effects across the cardiovascular system
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Interestingly, an exploration involving cybrid LHON cells revealed that dysfunctional complex I, marked by elevated ROS levels and augmented cytosolic Ca 2 ⁺ concentrations, provokes prolonged opening of permeability transition pores, leading to mitochondrial membrane depolarization [497]
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